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Florian named among the world’s most cited researchers — huge congrats to the whole MLO Lab team!
A proud moment: Florian has been listed as a Highly Cited Researcher 2025, placing him among the top 1% of scientists worldwide. This recognition reflects the shared work, ideas, and energy that move our lab forward every day.
Florian Buettner
Nov 14, 2025
1 min read
Our paper “Learning interpretable representations of single-cell multi-omics data with multi-output Gaussian processes” has been published in Nucleic Acids Research.
We present a unified framework that combines expressive neural embeddings with interpretable multi-output Gaussian processes for single-cell genomics. Joint representations of cells and genes reveal meaningful links between cell clusters and their marker genes via an interpretable gene-relevance map.
Zahra Moslehi
Aug 12, 2025
1 min read
An autonomous agent for auditing and improving the reliability of clinical AI models — now published.
We introduce ModelAuditor, a self-reflective agent that simulates clinically relevant distribution shifts and produces interpretable reports on likely failure modes. Across multiple medical imaging domains, it recovers up to 25% of performance lost under shift while providing actionable deployment insights.
Lukas Kuhn
Jul 8, 2025
1 min read
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Application-driven validation of posteriors in inverse problems, published in Medical Image Analysis.
We present the first systematic framework for application-driven validation of posterior-based methods in inverse problems. Adapting concepts from object detection enables mode-centric validation with interpretable, application-focused metrics, demonstrated on multiple medical imaging use cases.
Florian Buettner
Apr 1, 2025
1 min read
PDF
Our paper on bidirectional human-AI visual alignment is out at the ICLR 2025 Workshop!
We introduce LVLM-Aided Visual Alignment (LVLM-VA), which aligns small vision models with human domain knowledge using large vision-language models. A bidirectional interface translates model behavior into natural language and expert instructions into image-level critiques, improving performance while reducing fine-grained feedback needs.
Florian Buettner
Mar 6, 2025
1 min read
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Forget forgetting — our TMLR paper shows how uncertainty helps models keep their memory straight!
We analyze how predictive uncertainty can guide memory management to mitigate catastrophic forgetting and introduce a generalized-variance–based uncertainty measure. Uncertainty-aware sampling improves retention across tasks. Published in the Journal of Transactions on Machine Learning Research.
Giuseppe Serra
Mar 4, 2025
1 min read
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New at AISTATS: IUPM — a label-free method for reliable model monitoring under drift.
We propose IUPM, a label-free method for tracking performance under gradual distribution shifts using optimal transport. IUPM quantifies uncertainty in its estimates and guides targeted labeling to restore reliability, outperforming existing baselines across scenarios.
Florian Buettner
Jan 22, 2025
1 min read
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Our ICLR paper proves that not everything needs to be forgotten — tackling catastrophic forgetting head-on!
We propose an uncertainty-aware memory-based approach for online Federated Continual Learning. Using a Bregman Information estimator to guide selective replay, the method reduces catastrophic forgetting across modalities while preserving privacy and communication efficiency.
Giuseppe Serra
Jan 22, 2025
1 min read
PDF
Unsupervised and efficient — our latest work exposes and mitigates shortcut learning!
We introduce an unsupervised framework to detect and mitigate shortcut learning in transformers. The method improves both worst-group and average accuracy while reducing annotation effort, offering interpretable insights for experts and running efficiently on consumer hardware.
Lukas Kuhn
Jan 1, 2025
1 min read
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Our latest work on deep learning for metabolomics just appeared in Scientific Reports!
We introduce GEMNA, a deep learning framework for mass spectrometry–based metabolomics that uses graph and edge embeddings with anomaly detection. GEMNA outperforms traditional tools in untargeted studies, producing clearer clusters and improved biological insights.
Florian Buettner
Nov 28, 2024
1 min read
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